PHY906 in Colorectal
Cancer (page 2)
In addition to the antitumor effect, PHY906
was also examined as a modulator of host cytotoxicity induced by CPT-11.
Two factors were monitored in the experiments: body weight loss and
mortality.
We observed a dose-dependent behavior of PHY906
on weight loss in CPT-11 treated mice (Figure 2).
Figure 2.
PHY906 Decreases the Bodyweight Loss Induced by CPT-11
CPT-11 treated animals receiving supplemental treatment with 500 mg/kg,
bid, of PHY906 exhibited significant (p < 0.05) improvement
in maintaining body weight and recovered their original body weight
more rapidly. However, mice receiving 250 or 125 mg/kg, bid,
of PHY906 showed no difference in body weight loss compared to controls.
Figure 3.
PHY906 Decreases the Mortality Induced by CPT-11
Forty of 40 tumor-bearing mice (100%) survived treatment with PHY906 alone,
indicating no or very low toxicity from PHY906. In contrast,
treatment with CPT-11 alone resulted in only 36 of 45 tumor-bearing
mice (80%) surviving after 8 days. However, this survival rate
dramatically improved to 96% (24 of 25 mice) after receiving 4 days
of PHY906 treatment in combination with CPT-11. This suggests that
PHY906 treatment can protect mice against mortality induced by a single
dose of 400 mg/kg CPT-11.
